Prognostic value of secondary hyperaldosteronism in patients with chronic heart failure with preserved ejection fraction
نویسندگان
چکیده
Purpose : to investigate the prognostic value of secondary hyperaldosteronism patients with heart failure preserved ejection fraction. Materials and methods prospective cohort study included 158 Baseline blood aldosterone levels were determined in all patients. Hyperaldosteronemia was diagnosed when plasma level > 160 pg/ml. The primary endpoint all-cause mortality. Results at baseline, hyperaldosteronemia detected 59 (37.3%). Hyperaldosteronemic younger, had higher functional class NT-proBNP level, a rate comorbidity (all Ps <0.05). Over median follow‐up 32 (28-38) months, total 50 (37.6%) died. Cardiovascular death occurred (20.3%) cases, non-cardiovascular – 18 (11.4%) cases. A 65 (41.1%) hospitalized for HF. High associated significant (p <0.05) increase risk hospitalization HF (adjusted odds ratio (OR) 2.14, 95% confidence interval (CI) 1.34-9.68), (OR 1.64; CI 1.23-7.65, P = 0.033) 1.56; 95 % 1.14-11.3, 0.021). Conclusion Hyperaldosteronism fraction is an independent predictor failure, all-cause, cardiovascular inclusion existing prognosis models will help improve their predictive optimize management high-risk
منابع مشابه
Hospitalisation in Patients With Heart Failure With Preserved Ejection Fraction
Heart failure is highly prevalent with more than 50% of cases being patients with a preserved ejection fraction (HFPEF), a figure that is projected to increase due to the changing risk factor landscape, in particular the ageing population. Overall mortality is similar to patients with heart failure with reduced ejection fraction (HFREF), as are the rates of hospitalisation. Patients with HFPEF ...
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متن کاملHeart Failure With Preserved Ejection Fraction
Symptomatic heart failure, despite preserved left ventricular (LV) ejection fraction, is a well-recognized phenomenon. This manifestation of diastolic dysfunction is associated with increased morbidity and mortality and can be attributed to a variety of pathogeneses, including diabetes mellitus, hypertension, infiltrative processes, and obesity. Unlike in systolic heart failure, where LV ejecti...
متن کاملHeart Failure with Preserved Ejection Fraction
1. Demonstrate the association between heart failure with preserved ejection fraction (HFpEF) and survival. 2. Given a patient with heart failure (HF), recognize HFpEF on the basis of clinical signs and symptoms, physical examination, echocardiography, and radiographic findings. 3. Classify patients at high risk of hospitalization and mortality through assessing risk factors, clinical presentat...
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ژورنال
عنوان ژورنال: ??????????? ??????? ??? ??????
سال: 2021
ISSN: ['2618-7876', '2219-8075']
DOI: https://doi.org/10.21886/2219-8075-2021-12-2-81-91